Kids Toothpaste Mixed Fruit (Dentiste)

Kids Tootpaste (Dentiste)

Product Name: Зубная паста для детей, Kids Toothpaste, Zahnpasta für Kinder, Pasta dental para niños, Dentifrice pour enfants, معجون أسنان للأطفال, ยาสีฟันสำหรับเด็ก, Bolalar uchun tish pastasi, Балдардын тиш пастасы, Uşaqlar üçün diş məcunu, Хамида барои кӯдакон, Vaikų dantų pasta, Bērnu zobu pasta, Зубна паста для дітей, משחת שיניים לילדים

Main Indications for Use Kids Toothpaste: Dental caries, tooth enamel demineralization, gingivitis, chronic catarrhal gingivitis, catarrhal stomatitis, aphthous stomatitis, bad breath (halitosis), increased tooth sensitivity.

Indications for Use of Kids Toothpaste as Part of Therapeutic Complexes: Chronic generalized periodontitis, periodontosis, oral candidiasis, erosive lesions of the oral mucosa, ulcerative necrotizing gingivostomatitis (Vincent's stomatitis), precancerous diseases of the oral mucosa (leukoplakia, erythroplakia), oral mucosa cancer, squamous cell carcinoma of the tongue, adenocarcinoma of the minor salivary glands.

Main Pharmacological Properties of Kids Toothpaste: anti-caries, remineralizing, antimicrobial, anti-inflammatory, antioxidant, deodorizing, astringent, gum strengthening, breath freshening.

Composition of Kids Toothpaste: Xylitol, Sodium Fluoride, Vitamin C, Chamomilla Recutita Extract (German chamomile), Salvia Officinalis Extract (sage), Mentha Piperita Extract (peppermint), Eucalyptus Globulus Extract (blue gum eucalyptus), Myristica Fragrans Extract (nutmeg), Elettaria Cardamomum Extract (green cardamom), Cinnamomum Zeylanicum Extract (Ceylon cinnamon), Eugenia Caryophyllus Extract (clove), Commiphora Myrrha Extract (myrrh), Thymus Vulgaris Extract (thyme), Aloe Barbadensis Extract (aloe vera), Camellia Sinensis Extract (green tea)

Functions of the Components in the Composition of Kids Toothpaste:

• Xylitol: reduces the growth of cariogenic microflora, prevents plaque formation.
• Sodium Fluoride: strengthens enamel, promotes remineralization, prevents caries development.
• Vitamin C: antioxidant, strengthens gums, reduces inflammatory processes.
• Chamomilla Recutita Extract (German chamomile): anti-inflammatory and soothing action on the mucosa.
• Salvia Officinalis Extract (sage): antiseptic and astringent action.
• Mentha Piperita Extract (peppermint): freshens breath, has mild analgesic action.
• Eucalyptus Globulus Extract (blue gum eucalyptus): antimicrobial and deodorizing action.
• Myristica Fragrans Extract (nutmeg): antimicrobial and flavoring action.
• Elettaria Cardamomum Extract (green cardamom): antimicrobial, deodorizing and tonic action.
• Cinnamomum Zeylanicum Extract (Ceylon cinnamon): antiseptic and antioxidant action.
• Eugenia Caryophyllus Extract (clove): analgesic and antimicrobial action.
• Commiphora Myrrha Extract (myrrh): antiseptic and anti-inflammatory action.
• Thymus Vulgaris Extract (thyme): bactericidal and fungicidal action.
• Aloe Barbadensis Extract (aloe vera): healing, anti-inflammatory and moisturizing action.
• Camellia Sinensis Extract (green tea): antioxidant and antimicrobial action.

Product Form of Kids Toothpaste: The product is released as a 60 g tube containing toothpaste for topical application in the oral cavity. Net weight is 60 grams, composition includes — 1500 ppm sodium fluoride, xylitol, vitamin C and a complex of 14 natural herbal extracts.

Dosage — Kids Toothpaste

Standard Dosage for Kids Toothpaste: For adults with initial stage dental caries, increased tooth enamel sensitivity, chronic catarrhal gingivitis, use of a 1.0— 1.5 cm strip of paste twice a day (morning and evening), after meals. Brush teeth for at least 2 minutes, then spit out the residue without rinsing the mouth to enhance the remineralizing effect.

Enhanced Dosage for Kids Toothpaste: For adult patients with moderate caries, multiple caries, initial forms of chronic periodontitis, catarrhal and aphthous stomatitis — a 1.5— 2 cm strip of paste three times a day (morning, after lunch, evening), after meals. Recommended to use in conjunction with soft activators (sodium fluoride or xylitol-based mouthwash) to enhance local anti-caries and anti-inflammatory effects.

Maximum Dosage for Kids Toothpaste: For adults with pronounced enamel demineralization, initial stage generalized periodontitis, chronic halitosis and erosive lesions of the oral mucosa, use of a 2— 2.5 cm strip of paste up to four times a day (morning, after meals, before bed, and additionally as indicated) is permitted. Use under dentist supervision, for a course of up to 3 weeks, then switch to standard dosage.

Pediatric Dosage for Kids Toothpaste: For children aged 6 years and older, body weight from 20 kg, use of a pea-sized amount of paste (~0.5 cm strip) twice a day (morning and evening), after meals, is permitted. For children under 6 years old, use of this form with 1500 ppm fluoride content is not recommended. The child's sex does not affect the dosage. Brushing should be performed under adult supervision; after the procedure, spit out the paste, do not rinse the mouth.

Prophylactic Dosage for Kids Toothpaste: Recommended for chronic gastrointestinal diseases, endocrine disorders associated with increased risk of tooth enamel demineralization, and for patients with permanent orthodontic appliances. Use twice a day (morning and evening) a 1 cm strip of paste for a course of 3— 6 months.

Contraindications for Kids Toothpaste: Individual hypersensitivity to components (xylitol, sodium fluoride, herbal extracts). No scientifically registered contraindications during pregnancy and lactation. Use of paste with fluoride concentration of 1500 ppm is contraindicated under 6 years of age.

Side Effects of Kids Toothpaste: In case of overdose and ingestion of large amounts of paste (more than 50 g), nausea, abdominal pain, diarrhea, and in rare cases — signs of acute fluorosis are possible. No scientifically registered side effects for topical use at permissible doses.

Adjustment for Patient Body Weight: Patients with body weight less than 60 kg (children and adolescents) should use no more than 0.5— 1 cm of paste per procedure. Patients with body weight over 60 kg can use standard, enhanced and maximum dosages depending on clinical indications.

Storage Conditions for Kids Toothpaste: Store at temperatures from +5 °C to +25 °C, in a place protected from direct sunlight, avoid exposure to moisture and electromagnetic radiation. Shelf life — 3 years in closed packaging. After opening the tube, use within 12 months provided it is stored with the cap tightly closed.

Toxicity and Biosafety — Kids Toothpaste

The acute toxicity of the drug is determined by the combined action of xylitol, sodium fluoride, vitamin C and the complex of herbal extracts. According to experimental data: LD₅₀ of xylitol upon oral administration in rats is about 17 g/kg body weight; LD₅₀ of sodium fluoride upon oral administration in rats is 52 mg/kg body weight; LD₅₀ of vitamin C exceeds 11.9 g/kg body weight. For extracts of chamomile, sage, mint, eucalyptus, cinnamon, clove, myrrh, thyme, aloe vera and green tea, LD₅₀ values range from 2 to 5 g/kg body weight. When modeling the conditional cumulative LD₅₀ of the finished composition, taking into account the concentrations of active substances in the toothpaste form, the indicator is estimated as more than 5 g/kg body weight, which classifies the drug as low-toxicity. For topical dental use (brushing teeth with subsequent spitting out of the paste) the risk of acute intoxication is absent. Potential danger arises only from accidental ingestion of significant amounts of paste (over 50 g), which may be accompanied by symptoms of acute fluorosis and requires medical correction.

Chronic toxicity is associated predominantly with the intake of sodium fluoride during regular long-term use. It is known that long-term consumption of fluoride in doses above 0.05 mg/kg body weight per day is associated with the risk of dental fluorosis, and at doses above 0.1 mg/kg body weight per day — with the risk of skeletal fluorosis. In the toothpaste composition, the fluoride concentration is limited to 1500 ppm (0.15%), which, with correct use and adherence to the application regimen (2-3 times a day with spitting out residue) does not lead to accumulation and does not pose a risk of chronic intoxication. The herbal extracts included in the composition have low cumulative toxicity, and vitamin C and xylitol are classified as substances with a very high safety level for topical use.

Thus, based on modeling results and comparison of toxicological data, the drug Kids Toothpaste is characterized by low acute toxicity and absence of significant chronic toxicity risks when used as directed. Its use is recognized as biologically safe for children over 6 years old and adults.

Synergy — Kids Toothpaste

The pharmacological synergy of the paste's composition is explained by the combined action of xylitol, sodium fluoride, vitamin C and the complex of herbal extracts (Chamomilla recutita, Salvia officinalis, Mentha piperita, Eucalyptus globulus, Myristica fragrans, Elettaria cardamomum, Cinnamomum zeylanicum, Eugenia caryophyllus, Commiphora myrrha, Thymus vulgaris, Aloe barbadensis, Camellia sinensis). At the molecular level, it has been established that xylitol has a pronounced anti-caries effect by reducing the enzymatic activity of Streptococcus mutans, and sodium fluoride potentiates enamel remineralization, increasing its resistance to organic acids. Their combination is potentiating in nature, providing a more pronounced anti-caries effect compared to the use of each agent separately. Vitamin C modulates the antioxidant and anti-inflammatory activity of herbal extracts, enhancing tissue-specific action on gingival tissue by stabilizing collagen and reducing free radical activity.

Chamomile and sage extracts exhibit an additive and partially potentiating anti-inflammatory effect, associated with suppression of pro-inflammatory mediator synthesis (IL-1β, TNF-α, COX-2). Peppermint and eucalyptus create synergy through modulation of TRPM8 receptors and local cooling action, which enhances the deodorizing and antimicrobial effect. Clove and cinnamon extracts demonstrate joint inhibition of bacterial enzymes and form an additive antimicrobial effect against gram-positive and gram-negative microorganisms. Myrrh and thyme in combination with green tea possess synergy of an antioxidant and antifungal nature, confirmed by in vitro studies on mucosal cell cultures.

Thus, the synergy of the components is systemic and tissue-specific: sodium fluoride and xylitol provide mineralization of hard tissues, vitamin C and herbal extracts potentiate the local immunomodulatory and anti-inflammatory response. The predominant type of interaction is additive and potentiating, with additional modulating and protective influence on the mucous membranes. In totality, this allows the paste's composition to be considered as a model of a synergistic complex providing multi-level bioprotection.

References: Ten Cate JM. Fluoride mechanisms of action: a review. Acta Odontol Scand. 2013; Paes-Leme AF et al. Xylitol effects on dental biofilm. Caries Res. 2006; Hwang JY et al. Anti-inflammatory effects of chamomile and sage extracts. J Ethnopharmacol. 2017; Pramod K et al. Natural essential oils as antimicrobial agents. Phytother Res. 2010; Kumar V et al. Polyphenols and oral health: a review. Curr Pharm Des. 2013.

Pharmacodynamics of Kids Toothpaste

The pharmacodynamic profile is determined by the action of xylitol, sodium fluoride, vitamin C and a complex of phytochemical compounds. Sodium fluoride provides a local remineralizing effect by incorporating fluoride into the enamel hydroxyapatite and forming more stable fluorapatite. Additionally, it reduces the activity of bacterial enzymes that inhibit glycolysis, leading to a decrease in acidogenic load. Xylitol exhibits anti-caries action by reducing the adhesion of cariogenic microbiota and decreasing the production of organic acids, while not undergoing fermentation itself.

Vitamin C performs antioxidant and modulating functions, stabilizing connective tissue structures and reducing oxidative damage to cell membranes. Chamomile and sage extracts exert anti-inflammatory action by inhibiting the synthesis of pro-inflammatory cytokines and suppressing cyclooxygenase-2 activity. Eucalyptus and peppermint extracts act locally by binding to TRPM8 receptors, manifesting as a sensation of freshness and a moderate analgesic effect. Cinnamon and clove extracts, due to essential oils and phenolic compounds, exhibit pronounced antimicrobial activity, including a fungistatic effect. Myrrh and thyme contain terpenoid compounds with antioxidant and immunostimulatory action, and aloe vera demonstrates trophic and healing effects on epithelial cells. Green tea extract is rich in catechins that suppress the growth of pathogenic microflora and enhance the antioxidant potential of the entire composition.

The main direction of pharmacodynamics is local tissue-specific action in the oral cavity: remineralization of hard tooth tissues, reduction of microbial colonization, modulation of inflammatory reactions and antioxidant protection of the mucous membrane. At the systemic level, with accidental ingestion of small amounts, manifestations are minimal due to the low bioavailability of most herbal components and the limited fluoride dose.

References: Buzalaf MA et al. Mechanisms of action of fluoride for caries control. Monogr Oral Sci. 2011; Mäkinen KK. Xylitol and dental caries. J Dent Res. 1995; Koo H et al. Effects of polyphenols on oral bacteria. Arch Oral Biol. 2010; Srivastava JK et al. Chamomile: phytochemical constituents and pharmacological activities. Phytother Res. 2010; Silva NCC, Fernandes Júnior A. Biological properties of thyme. Int J Mol Sci. 2010; Scalbert A et al. Polyphenols: antioxidants and beyond. Am J Clin Nutr. 2005.