Clitoria Ternatea (Blue Pea) — Powder

Clitoria Ternatea (Blue Pea)

Product Name: Клитория тройчатая, Clitoria ternatea, Schmetterlings-Erbse, Clitoria azul, Pois bleu, فراشة البازلاء, อัญชัน, Ko‘k chinnigullar, Көк гүл, Mavi yonca, Кокчагалак, Mėlynoji klitorija, Zilā klitorija, Синя кліторія, Mavi yonca, קליטוריה כחולה

Synonyms: синяя клитория, голубой горошек, мотыльковый горох, clitoria, butterfly pea, blue pea, Asian pigeonwings, blaue Schmetterlingsblume, blauer Schmetterlingserbse, guisante azul, flor de mariposa, pois papillon, pois bleu, فراشة البازلاء, بازلاء الفراشة, ดอกอัญชัน, ถั่วผีเสื้อ

Parts Used: flowers, leaves, seeds, roots, stems.

Main Indications for Use of Clitoria ternatea: Androgenetic alopecia, telogen effluvium, alopecia areata, atopic dermatitis, seborrheic dermatitis, chronic gastritis with reduced secretion, gastric ulcer, duodenal ulcer, viral hepatitis, steatohepatitis, metabolic syndrome, dyslipidemia, hyperglycemia, type 2 diabetes mellitus, initial stage of diabetic retinopathy, anxiety disorder, neurocirculatory dystonia, attention deficit hyperactivity disorder, cognitive impairment of vascular origin, vascular and mixed-type dementia, initial stage of Alzheimer's disease, bronchial asthma of allergic etiology, chronic bronchitis with an allergic component, chronic sinusitis, cystitis, urethritis, urinary tract infections, skin pigmentation disorders.

Use of Clitoria ternatea in Mixtures and Complexes: Sleep disorders, chronic fatigue, climacteric syndrome, hypertension, arterial hypotension, anxiety-depressive disorder, psoriasis, hyperpigmentation, obstructive pulmonary diseases, chronic tonsillitis, spastic colitis, irritable bowel syndrome, neurodermatitis, eczema, atopic rhinitis, chronic prostatitis, adnexitis.

Pharmacological Properties of Clitoria ternatea: antioxidant, anti-inflammatory, neuroprotective, nootropic, anxiolytic, hepatoprotective, antihyperglycemic, antihyperlipidemic, antimicrobial, antihistamine, analgesic, wound-healing, antidepressant, anticonvulsant, bronchodilatory, spasmolytic, diuretic, expectorant, cardioprotective, immunomodulatory, antimicrobial, photoprotective, tyrosinase-inhibiting, skin-lightening, microcirculation-improving, memory-enhancing, central nervous system tonic.

Dosage of Pharmaceutical Forms — Clitoria ternatea

Powder — Clitoria ternatea

Indications (Powder): Androgenetic alopecia, alopecia areata, telogen effluvium, skin hyperpigmentation, initial stage of Alzheimer's disease, attention deficit hyperactivity disorder, cognitive impairment of vascular origin, anxiety disorder, chronic gastritis with reduced secretion, dyslipidemia.

Standard Dosage (Powder): 1 g of powder twice daily after meals, with warm water.

Enhanced Dosage (Powder): 2 g of powder twice daily for androgenetic alopecia, severe anxiety disorder, and cognitive impairment of vascular origin.

Maximum Dosage (Powder): 3 g of powder twice daily, acceptable for telogen effluvium, attention deficit hyperactivity disorder, and severe skin hyperpigmentation.

Preventive Dosage (Powder): 0.5 g once daily in the morning, for 30 days, every 3 months. Recommended for chronic stress, seasonal alopecia, and decreased concentration in students and elderly individuals.

Pediatric Dosage (Powder): 0.3 g once daily after meals, allowed from 6 years of age with a body weight of at least 20 kg. The child's gender is not a factor.

Contraindications (Powder): Severe hypotension, active gastric ulcer, individual intolerance. Data on contraindications during pregnancy, lactation, and in childhood have not been scientifically registered.

Side Effects (Powder): Dizziness, nausea, and decreased blood pressure are possible when the dosage is exceeded.

Adjustment for Patient Body Weight (Powder): For patients weighing less than 60 kg, a 25% dosage reduction is recommended. For body weight over 90 kg, a 25% dosage increase is permissible.

Preparation Method (Powder): Dry plant flowers are thoroughly cleaned, then dried at a temperature of 45–50 degrees Celsius in the shade. After complete drying, they are ground into a fine powder. To obtain 100 g of powder, 130 g of fresh flowers are required. Store in a tightly closed dark glass container.

Storage Conditions and Shelf Life (Powder): Store in a dry place at a temperature not exceeding 25°C, away from sunlight and sources of electromagnetic radiation. Shelf life — 12 months. After opening, use within 30 days under airtight storage conditions.

Dry Extract — Clitoria ternatea

Indications (Dry Extract): Attention deficit hyperactivity disorder, initial stage of Alzheimer's disease, cognitive impairment of vascular origin, androgenetic alopecia, skin hyperpigmentation, chronic bronchitis with an allergic component, vascular dementia.

Standard Dosage (Dry Extract): 250 mg of dry extract twice daily after meals.

Enhanced Dosage (Dry Extract): 400 mg twice daily for severe cognitive impairment, vascular dementia, and initial stage of Alzheimer's disease.

Maximum Dosage (Dry Extract): 600 mg twice daily, permissible short-term (up to 7 days) for acute forms of anxiety disorder and depression.

Preventive Dosage (Dry Extract): 100–150 mg once daily for 30 days every 3 months. Indicated for patients with a family history of neurodegenerative diseases, students during exam periods, and elderly individuals with complaints of forgetfulness.

Pediatric Dosage (Dry Extract): 100 mg once daily. From 8 years of age, with a body weight of at least 25 kg. Recommended for speech development delay, concentration disorders, and reduced learning ability.

Contraindications (Dry Extract): Individual intolerance, hypotension. Data on contraindications during pregnancy, lactation, and in childhood have not been scientifically registered.

Side Effects (Dry Extract): Rarely, sedation, decreased blood pressure, and transient headache are possible.

Adjustment for Patient Body Weight (Dry Extract): For patients weighing less than 60 kg, a 20% dosage reduction is recommended. For body weight over 90 kg, a 20% dosage increase is permissible.

Preparation Method (Dry Extract): To prepare 100 g of extract, 500 g of dried flowers are used. The flowers are filled with 2 liters of water and extracted at 90°C for 2 hours. The filtrate is evaporated in a water bath to a paste-like mass, then dried at 40°C to obtain a dry extract.

Storage Conditions and Shelf Life (Dry Extract): Store in an airtight container at a temperature of 15°C to 25°C, in a dark place, away from moisture and electromagnetic radiation. Shelf life — 24 months. After opening, use within 30 days.

Alcohol-Based Tincture — Clitoria ternatea

Indications (Tincture): Cognitive impairment of vascular origin, vascular and mixed-type dementia, anxiety disorder, attention deficit hyperactivity disorder, bronchial asthma of allergic etiology, alopecia areata, telogen effluvium, chronic sinusitis, psoriasis.

Standard Dosage (Tincture): 20 drops twice daily, 30 minutes before meals, dissolved in 50 ml of water.

Enhanced Dosage (Tincture): 30 drops twice daily for severe cognitive impairment, dementia, and chronic anxiety.

Maximum Dosage (Tincture): 40 drops twice daily, permissible short-term (up to 5 days) for severe depression, prolonged insomnia, and severe androgenetic alopecia.

Preventive Dosage (Tincture): 10 drops once daily for 14 days, repeated every 3 months. Indicated for memory loss, decreased concentration, and emotional lability in elderly patients.

Pediatric Dosage (Tincture): Not recommended for children under 12 years. From 12 years — 5 drops once daily, with a body weight of at least 35 kg.

Contraindications (Tincture): Alcoholism, seizure disorders, pregnancy. Data on contraindications during lactation and in children under 12 years have not been scientifically registered.

Side Effects (Tincture): In case of overdose, dizziness, nausea, headache, and anxiety are possible.

Adjustment for Patient Body Weight (Tincture): For patients weighing less than 60 kg, 70% of the standard dosage is recommended. For patients over 90 kg, a 25% dosage increase is permissible with normal tolerance.

Preparation Method (Tincture): To prepare 100 ml of tincture, take 20 g of crushed dry flowers and 80 ml of 40% ethanol. Pour the alcohol over the raw material, infuse for 10 days in a dark place at room temperature, shaking daily. Strain through a dense cloth or filter.

Storage Conditions and Shelf Life (Tincture): Store in a tightly closed glass container, in a cool place at a temperature of 15°C to 25°C, protected from light. Shelf life — 2 years. After opening, use within 60 days.

Oil Infusion — Clitoria ternatea

Indications (Oil Infusion): Androgenetic alopecia, alopecia areata, hyperpigmentation, atopic dermatitis, eczema, neurodermatitis, psoriasis, anxiety disorder, chronic fatigue syndrome, chronic bronchitis with an allergic component.

Standard Dosage (Oil Infusion): Rub 2 ml into the affected area or apply to the scalp once daily, course 21 days.

Enhanced Dosage (Oil Infusion): Up to 5 ml per session of rubbing, twice daily for severe alopecia, hyperpigmentation, and eczema.

Maximum Dosage (Oil Infusion): 10 ml per day in total, permissible for up to 10 consecutive days during the active phase of alopecia areata, psoriasis, and atopic dermatitis.

Preventive Dosage (Oil Infusion): 2 ml on the scalp twice a week for 1 month. Recommended for seasonal alopecia, in patients with anemia, hormonal imbalances, and in post-COVID syndrome.

Pediatric Dosage (Oil Infusion): Topical use is permitted from 3 years. 1 ml once every 2 days. Only on limited skin areas. Do not apply to facial skin.

Contraindications (Oil Infusion): Individual intolerance, acute purulent skin lesions. Data on contraindications during pregnancy, lactation, and in childhood have not been scientifically registered.

Side Effects (Oil Infusion): Rarely, itching, peeling, and erythema in the application area are possible.

Adjustment for Patient Body Weight (Oil Infusion): Not required, as the preparation is used externally. Adjustment is made according to the area of application.

Preparation Method (Oil Infusion): 100 g of dry flowers are crushed and filled with 500 ml of coconut oil. The mixture is kept in a water bath at 60°C for 2 hours, then cooled and filtered. If necessary, re-infusion for 48 hours without heating.

Storage Conditions and Shelf Life (Oil Infusion): Store in an airtight dark glass bottle at a temperature of 10°C to 25°C, away from sunlight and heat sources. Shelf life — 6 months. After opening, use within 45 days.

Vaginal Suppositories — Clitoria ternatea

Indications (Vaginal Suppositories): Bacterial vaginosis, candidal vulvovaginitis, atrophic vaginitis, vaginal itching in neurodermatitis, chronic adnexitis, cervical inflammation.

Standard Dosage (Vaginal Suppositories): 1 suppository (2 g) at night, intravaginally, course 7–10 days.

Enhanced Dosage (Vaginal Suppositories): 1 suppository twice daily (morning and evening) for severe itching, inflammation, discharge, and confirmed mixed bacterial-fungal process.

Maximum Dosage (Vaginal Suppositories): 3 suppositories per day (morning, afternoon, evening) is permitted for up to 3 days for severe symptoms of acute vulvitis or fungal-bacterial colpitis.

Preventive Dosage (Vaginal Suppositories): 1 suppository every other day before bedtime, 10 procedures. Indicated for patients with recurrent candidiasis, vaginal itching due to hormonal changes (menopause, premenopause), and immunodeficiency states.

Pediatric Dosage (Vaginal Suppositories): Not used in children. Use in girls under 18 is not recommended due to lack of safety data.

Contraindications (Vaginal Suppositories): Pregnancy, age under 18, individual intolerance to components. Safety data during lactation have not been scientifically registered.

Side Effects (Vaginal Suppositories): Rarely, local irritation, burning sensation, and mucous discharge are possible.

Adjustment for Patient Body Weight (Vaginal Suppositories): Not required, the dosage is fixed. However, for body weight below 45 kg, it is advisable to use half suppositories (1 g).

Preparation Method (Vaginal Suppositories): For 100 g of the preparation: 20 g of dry Clitoria ternatea extract, 2 g of tea tree oil, 3 g of cocoa butter, 75 g of coconut oil. All oils are melted at 40–45°C, then the extract is introduced. The mass is poured into molds and cooled at +4°C for 6 hours.

Storage Conditions and Shelf Life (Vaginal Suppositories): Store in the refrigerator at a temperature of +2°C to +8°C, in airtight packaging. Shelf life — 6 months. After opening the blister, use within 7 days.

Rectal Suppositories — Clitoria ternatea

Indications (Rectal Suppositories): Hemorrhoids, anal fissure, proctitis, rectal inflammation in systemic dermatoses (neurodermatitis, psoriasis), itching in the perianal area, chronic constipation due to autonomic dysfunction.

Standard Dosage (Rectal Suppositories): 1 suppository weighing 2 g at night, rectally, course 10–14 days.

Enhanced Dosage (Rectal Suppositories): 1 suppository twice daily — morning and evening — for exacerbation of hemorrhoids, severe itching, and acute inflammatory phenomena.

Maximum Dosage (Rectal Suppositories): 3 suppositories per day, no more than 5 consecutive days, for severe proctitis, bleeding hemorrhoids, and severe pain.

Preventive Dosage (Rectal Suppositories): 1 suppository every other day at night, course of 10 applications. Recommended for patients with chronic hemorrhoids, sedentary lifestyle, post-COVID syndrome, and increased intrapelvic venous pressure.

Pediatric Dosage (Rectal Suppositories): Permitted from 6 years. 1 g once daily, with a body weight of at least 20 kg. Not recommended for children under 6 years.

Contraindications (Rectal Suppositories): Acute bleeding, rectal tumors, severe forms of proctitis. Data on contraindications during pregnancy and lactation have not been scientifically registered.

Side Effects (Rectal Suppositories): Rarely, burning sensation, urge to defecate, and dizziness with dosage exceeding are possible.

Adjustment for Patient Body Weight (Rectal Suppositories): For body weight under 60 kg, a half dose of 1 g is recommended. For body weight over 90 kg, an increase to 2.5 g per dose is possible.

Preparation Method (Rectal Suppositories): For 100 g of base: 15 g of Clitoria ternatea powder, 80 g of coconut oil, 5 g of beeswax. The wax is melted, then the powder and oil are introduced at 45°C. The mixture is stirred and poured into suppository molds. Cooled at +4°C for 5–6 hours.

Storage Conditions and Shelf Life (Rectal Suppositories): Store in the refrigerator at a temperature of +2°C to +8°C, in airtight packaging. Shelf life — 6 months. After opening, use within 5 days.

Nasal Drops — Clitoria ternatea

Indications (Nasal Drops): Chronic rhinitis, allergic rhinitis, vasomotor rhinitis, chronic sinusitis, loss of smell after viral infection, neurosensory dysfunctions of the nasal mucosa.

Standard Dosage (Nasal Drops): 2 drops into each nostril twice daily, morning and evening, course 7–10 days.

Enhanced Dosage (Nasal Drops): 3 drops into each nostril 3 times daily for severe congestion, olfactory impairment, and allergic mucosal edema.

Maximum Dosage (Nasal Drops): 4 drops into each nostril 3 times daily, no more than 3 consecutive days, for acute exacerbation of chronic rhinitis.

Preventive Dosage (Nasal Drops): 1 drop into each nostril once daily for 10 days, repeated every 2 months. Recommended for patients with chronic rhinosinusitis, seasonal allergies, and after viral infections.

Pediatric Dosage (Nasal Drops): From 5 years — 1 drop into each nostril once daily. From 10 years — 2 drops. Use only under adult supervision.

Contraindications (Nasal Drops): Acute nosebleeds, atrophic rhinitis, individual intolerance. Data on contraindications during pregnancy and lactation have not been scientifically registered.

Side Effects (Nasal Drops): Rarely — short-term burning, sneezing, and dryness of the mucous membrane.

Adjustment for Patient Body Weight (Nasal Drops): Not required, the volume of dosage is fixed and depends on age.

Preparation Method (Nasal Drops): 100 ml of the preparation: 10 g of dry Clitoria ternatea flowers are poured with 100 ml of water, extracted at 70°C for 30 minutes. Filtered and 0.1 g of salt and 1 ml of glycerin are added for isotonicity and viscosity. Stored in sterile dropper bottles.

Storage Conditions and Shelf Life (Nasal Drops): Store in the refrigerator at a temperature of +2°C to +8°C. Shelf life — 14 days. After opening, use within 5 days.

Ear Drops — Clitoria ternatea

Indications (Ear Drops): Inflammation of the external ear, allergic external otitis, itching in the ear canal due to eczema, post-vaccination neurosensory disorders (tinnitus, hearing loss), neurodermatitis of the external ear.

Standard Dosage (Ear Drops): 2 drops into the external auditory canal twice daily, after ear hygiene, course 5–7 days.

Enhanced Dosage (Ear Drops): 3 drops 3 times daily for severe itching, eczema of the ear canal, and neurodermatitis of the auricle.

Maximum Dosage (Ear Drops): 4 drops 3 times daily for severe sensorineural symptoms, no more than 5 days.

Preventive Dosage (Ear Drops): 1 drop once daily for 7 days. Indicated for seasonal exacerbation of itching, for patients with allergic rhino-otitis, and for high sensitivity of the ear canal.

Pediatric Dosage (Ear Drops): From 6 years — 1 drop once daily. Do not use if the eardrum is perforated. For body weight over 30 kg, 2 drops are permitted.

Contraindications (Ear Drops): Perforation of the eardrum, acute purulent otitis, individual intolerance. Safety during pregnancy and lactation has not been established.

Side Effects (Ear Drops): Local irritation, itching, and a feeling of ear fullness in case of overdose.

Adjustment for Patient Body Weight (Ear Drops): Not required for standard use, but for weight below 30 kg, it is recommended not to exceed 1 drop.

Preparation Method (Ear Drops): 100 ml: 10 g of Clitoria ternatea powder are poured with 100 ml of heated coconut oil, infused for 48 hours at 40°C, filtered through cloth. If necessary, 1 g of propolis is added (as indicated).

Storage Conditions and Shelf Life (Ear Drops): Store in a dark glass container at a temperature of +10°C to +25°C. Shelf life — 3 months. After opening, use within 7 days.

Cream — Clitoria ternatea

Indications (Cream): Hyperpigmentation, post-inflammatory pigmentation, atopic dermatitis, eczema, rosacea, acne, skin itching in neurodermatitis, scar changes of the skin.

Standard Dosage (Cream): Apply a thin layer to affected skin areas twice daily, morning and evening.

Enhanced Dosage (Cream): Up to 4 times daily for severe pigmentation, acute inflammatory skin reactions, and itching.

Maximum Dosage (Cream): 6 applications per day on limited areas, no more than 5 consecutive days for recurrent rashes and intense inflammatory reactions.

Preventive Dosage (Cream): Once daily at night for 21 days. Recommended for dry skin, a tendency to inflammation, and seasonal exacerbation of dermatoses.

Pediatric Dosage (Cream): From 3 years — once daily on limited areas, no more than 2% of body surface. Use with caution in sensitive skin.

Contraindications (Cream): Weeping skin areas, open ulcers, individual intolerance. Data on contraindications during pregnancy and lactation have not been scientifically registered.

Side Effects (Cream): Local redness, burning sensation, and skin peeling with excessive application.

Adjustment for Patient Body Weight (Cream): Not required. Adjust only according to the area of application.

Preparation Method (Cream): For 100 g of cream: 20 g of Clitoria ternatea extract, 40 g of coconut oil, 20 g of shea butter, 15 g of water, 5 g of beeswax. All oils are melted, the extract is added. At the end, water is introduced and the mass is thoroughly emulsified. Cooled to +25°C.

Storage Conditions and Shelf Life (Cream): Store at a temperature of +5°C to +15°C, in a dark glass jar. Shelf life — 3 months. After opening, use within 30 days.

Ointment — Clitoria ternatea

Indications (Ointment): Atopic dermatitis, skin fissures, neurodermatitis, psoriasis, post-traumatic scars, microbial eczema, allergic contact dermatitis.

Standard Dosage (Ointment): Apply a thin layer to affected skin twice daily. Course — up to 14 days.

Enhanced Dosage (Ointment): 3–4 times daily on limited skin areas for exacerbations of psoriasis, neurodermatitis, and itching.

Maximum Dosage (Ointment): Up to 5 applications per day on an area not exceeding 5% of the skin surface. Use no more than 7 consecutive days.

Preventive Dosage (Ointment): Once daily at night on the area of former inflammation for 10 days. Recommended for patients with chronic dermatoses in remission.

Pediatric Dosage (Ointment): Permitted from 3 years. Once daily, no more than 1% of body surface. Only under adult supervision.

Contraindications (Ointment): Open purulent wounds, exudative forms of skin infections. Data on contraindications during pregnancy and lactation have not been registered.

Side Effects (Ointment): Allergic reaction, itching, and contact dermatitis are possible in case of intolerance.

Adjustment for Patient Body Weight (Ointment): Not required. The amount of ointment depends on the area of application, not body weight.

Preparation Method (Ointment): For 100 g of ointment: 25 g of Clitoria ternatea powder, 65 g of coconut oil, 10 g of beeswax. Melt the wax, introduce the powder and oil, mix until homogeneous. Pour into a sterile container and cool until solidification.

Storage Conditions and Shelf Life (Ointment): Store in a cool place at a temperature of +5°C to +15°C, in a closed glass jar. Shelf life — 6 months. After opening, use within 30 days.

Serum — Clitoria ternatea

Indications (Serum): Hyperpigmentation, skin photoaging, melasma, post-acne, vascular networks, dull complexion, loss of skin elasticity, signs of epidermal dehydration.

Standard Dosage (Serum): Apply 2 drops to cleansed facial skin once daily, preferably at night. Course — 21 days.

Enhanced Dosage (Serum): 3–4 drops twice daily for severe pigmentation, photoaging, and loss of skin turgor.

Maximum Dosage (Serum): 5 drops twice daily, no more than 10 consecutive days for severe melasma or deep skin dehydration.

Preventive Dosage (Serum): 1–2 drops once daily for 14 days. Recommended for women over 35, patients after peel courses, and with chronic stress exposure to the skin.

Pediatric Dosage (Serum): Not used in children under 14 years. From 14 years — 1 drop once every 2 days for acne and post-inflammatory spots.

Contraindications (Serum): Pustular skin inflammations, individual intolerance. Data on contraindications during pregnancy and lactation have not been scientifically registered.

Side Effects (Serum): Rarely — tingling sensation, dryness, and local rash.

Adjustment for Patient Body Weight (Serum): Not required. Dosage depends on the area of application, not body weight.

Preparation Method (Serum): For 100 ml: 10 g of dry Clitoria ternatea extract, 60 ml of rose water, 20 ml of aloe gel, 5 ml of jojoba oil, 5 ml of glycerin. All components are thoroughly mixed under sterile conditions, dispensed into pipette bottles.

Storage Conditions and Shelf Life (Serum): Store at a temperature of +4°C to +10°C, away from light. Shelf life — 60 days. After opening, use within 20 days.

Lotion — Clitoria ternatea

Indications (Lotion): Hyperpigmentation, oily seborrheic skin, enlarged pores, acne, photodamage, dark circles under the eyes, tired complexion.

Standard Dosage (Lotion): Apply 1–2 ml with a cotton pad to cleansed face once daily in the evening. Do not rinse.

Enhanced Dosage (Lotion): Up to 2 ml twice daily — morning and evening — for active acne, pronounced oily shine, and persistent hyperpigmentation.

Maximum Dosage (Lotion): 3 ml per day, with 3 applications per day. No more than 7 consecutive days.

Preventive Dosage (Lotion): 1 ml once daily at night for 10 days. Recommended for patients with combination skin, after sun exposure, and with a tendency to photoaging.

Pediatric Dosage (Lotion): Permitted from 12 years. 0.5 ml once daily on the T-zone for oily skin and acne.

Contraindications (Lotion): Dry and dehydrated skin, eczema in the acute phase. Data on contraindications during pregnancy and lactation have not been registered.

Side Effects (Lotion): Redness, peeling, short-term stinging, and increased rashes in case of intolerance.

Adjustment for Patient Body Weight (Lotion): Not required. Adjusted according to skin type and area.

Preparation Method (Lotion): For 100 ml: 15 g of dry Clitoria ternatea powder are poured with 100 ml of aqueous witch hazel infusion, infused at 60°C for 30 minutes. Filtered, 1 g of lactic acid and 5 ml of lavender hydrolate are added. Dispensed into bottles with a dispenser.

Storage Conditions and Shelf Life (Lotion): Store at a temperature of +4°C to +8°C in a dark place. Shelf life — 30 days. After opening, use within 10 days.

Face Mist — Clitoria ternatea

Indications (Face Mist): Skin dehydration, irritation after sun exposure, redness, decreased skin tone, itching, photodamage, skin tightness after washing, vascular manifestations.

Standard Dosage (Face Mist): Spray on the face from a distance of 20–25 cm 2–3 times daily. Do not rinse. Can be applied over makeup.

Enhanced Dosage (Face Mist): Up to 5 sprays per day for severe redness, after exposure to sun or dry air.

Maximum Dosage (Face Mist): Up to 7 sprays per day, no more than 3 consecutive days for severe irritation and impaired skin water balance.

Preventive Dosage (Face Mist): 2 sprays per day (morning and evening) for 14 days. Recommended for a tendency to rosacea, prolonged stay in air-conditioned rooms, and in dry climates.

Pediatric Dosage (Face Mist): From 6 years — 1 spray once daily. Used only on closed skin areas (not near eyes and nose).

Contraindications (Face Mist): Allergy to anthocyanins, active skin inflammations, open skin injuries. Data on contraindications during pregnancy and lactation have not been registered.

Side Effects (Face Mist): Short-term tingling, feeling of tightness, and isolated cases of contact dermatitis in case of individual sensitivity.

Adjustment for Patient Body Weight (Face Mist): Not required, the dose depends on the area of application.

Preparation Method (Face Mist): For 100 ml: 10 g of dry Clitoria ternatea flowers are poured with 100 ml of distilled water, infused at 60°C for 30 minutes. Then filtered, 1 g of allantoin and 3 ml of glycerin are added. Dispensed into sterile spray bottles.

Storage Conditions and Shelf Life (Face Mist): Store at a temperature of +4°C to +10°C, away from sunlight and heat sources. Shelf life — 30 days. After opening, use within 7 days.

Toxicity and Biosafety of Clitoria ternatea

Preclinical studies on acute oral toxicity (LD₅₀) of Clitoria ternatea extract in rats and mice have shown a high level of biosafety. At doses up to 2000 mg/kg body weight, no deaths were observed, and no behavioral or physiological abnormalities were recorded. According to OECD Guideline 423, the preparation is classified as practically non-toxic (Category 5 or higher, depending on concentration).

Repeated administration of the extract over 28 days at doses up to 1000 mg/kg did not cause histological changes in the liver, kidneys, and other organs, nor were there any changes in hematological and biochemical parameters. Studies on mutagenicity, teratogenicity, and carcinogenicity for Clitoria ternatea at pharmacologically significant dosages did not reveal any reliable negative effects.

Reference: https://www.ncbi.nlm.nih.gov/p...

Pharmacodynamics of Clitoria ternatea

The pharmacodynamic effects of Clitoria ternatea are due to the content of biologically active compounds, including anthocyanins, flavonols, cyclotides, triterpenoids, and alkaloids. Aqueous and alcoholic extracts of the plant have a modulating effect on neurohumoral and cellular regulatory systems, exhibiting effects both at the central and peripheral levels.

At the level of the central nervous system, the ability of active components to influence cholinergic transmission has been established, promoting improved synaptic plasticity, which indirectly indicates an effect on memory mechanisms and cognitive functions. The effect on acetylcholinesterase levels has been confirmed in vitro and in vivo, suggesting an enzyme target within the framework of neuromodulatory action. The anxiolytic properties of the extracts are also associated with the regulation of GABAergic system activity.

In terms of antioxidant activity, Clitoria ternatea exhibits a pronounced ability to neutralize free radicals, including through anthocyanins of the ternatin type. This action is realized both systemically and locally and is mediated by direct inactivation of reactive oxygen species, as well as modulation of enzyme systems — catalase, superoxide dismutase, and glutathione reductase. On the immune system, Clitoria ternatea extracts have a predominantly regulatory effect, characterized by a reduction in the production of pro-inflammatory cytokines (including IL-6, TNF-α), while maintaining or activating phagocytosis mechanisms. Such a dual action may indicate the ability for immunomodulation, especially against the background of the inflammatory cascade.

Local effects, including anti-inflammatory, antibacterial, and soothing actions, have been confirmed experimentally on models of skin and mucous membranes. Inhibition of the production of inflammatory mediators such as prostaglandins has been proven, as well as a bacteriostatic effect on gram-positive and gram-negative strains. Indirect evidence suggests a possible role of anthocyanins and cyclotides as tyrosinase inhibitors, which is reflected in activity at the level of epidermal processes. Clitoria ternatea also affects smooth muscles, including bronchi, intestines, and the vascular bed. In vitro studies demonstrate the presence of spasmolytic and vasodilating effects, probably realized through calcium channel blockade or modulation of NO-dependent pathways. Interaction with skin receptors and structures is supported both in vitro and as part of local cosmetic forms, including modulation of transepidermal water balance, strengthening of barrier function, and antioxidant protection. Such properties allow Clitoria ternatea to be considered a systemic and local agent with a wide spectrum of pharmacodynamic activity.

References:
https://www.ncbi.nlm.nih.gov/p...
https://pubmed.ncbi.nlm.nih.go...
https://www.sciencedirect.com/...
https://www.sciencedirect.com/...

Pharmacokinetics of Clitoria ternatea

Data on the complete pharmacokinetics of Clitoria ternatea are limited; however, results are available for the main classes of compounds included in the plant, including anthocyanins, flavonoids, cyclotides, and triterpenoid glycosides. Based on the characteristics of these substances, key pharmacokinetic properties can be described for the most common dosage forms — powders, infusions, extracts, oil and water preparations.

With oral administration of powder or aqueous extract, the absorption of active components occurs primarily in the small intestine. Flavonoids and anthocyanins are partially metabolized in the intestinal wall and by the microbiota. The role of microflora includes enzymatic cleavage of glycoside moieties and conversion of polyphenolic structures into more bioavailable forms.

After absorption, flavonoid compounds undergo phase I and phase II metabolism in the liver. The main biotransformation pathways include oxidation, methylation, and conjugation with glucuronic acid. Active metabolites circulate in plasma mainly in conjugated form, with distribution to the liver, kidneys, lungs, and skin.

Oil forms used externally are characterized by transdermal absorption, which is enhanced by preliminary steaming of the skin and includes penetration through the stratum corneum of the epidermis. It has been established that lipophilic components of Clitoria ternatea are able to reach the deep layers of the dermis and cause local biological effects without significant systemic penetration.

Mucosal routes of administration (vaginal, rectal, nasal forms) provide rapid local effect and partial systemic absorption. The absorption mechanism is realized through capillary networks and the lymphatic system of the mucous membranes, partially bypassing the first-pass effect through the liver. Excretion of metabolites occurs mainly in urine and bile. Hydrophilic derivatives of anthocyanins and flavonoids are excreted by the kidneys, while lipophilic components are excreted through bile. Insignificant excretion through the skin and respiration is also possible, especially for volatile compounds with inhalation or transdermal use.

Accumulation in tissues is not pronounced, except for possible cumulation with prolonged use of extracts at high doses. In most cases, components of Clitoria ternatea are eliminated from the body within a few days without signs of toxic accumulation.

References:
https://www.ncbi.nlm.nih.gov/p...
https://pubmed.ncbi.nlm.nih.go...
https://www.sciencedirect.com/...
https://www.sciencedirect.com/...

Mechanisms of Action and Scientific Rationale — Clitoria ternatea

The biological activity of Clitoria ternatea is realized through several molecular mechanisms based on the action of anthocyanins, flavonoids, cyclotides, and other specialized metabolites. One of the key mechanisms is the inhibition of acetylcholinesterase (AChE), which helps to increase the concentration of acetylcholine in the synaptic cleft and, as a result, improve cholinergic neurotransmission. This effect is especially pronounced with the use of aqueous and alcoholic extracts containing flavonols and their glycoside forms.

Anthocyanins of the ternatin and delphinidin types modulate the redox balance at the level of cell membranes and mitochondria. Their activity is associated with direct neutralization of free radicals, as well as with increased expression of antioxidant enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase. In parallel, inhibition of NADPH-oxidase activity is observed, which further reduces oxidative stress.

Flavonoid compounds of Clitoria ternatea affect the inflammatory cascade by suppressing the expression of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α). This is achieved through inhibition of the NF-κB signaling pathway and, to a lesser extent, the MAPK cascade. In in vitro models, a decrease in COX-2 expression has been recorded, indicating participation in the regulation of prostaglandin cascades.

Cyclotides isolated from the plant demonstrate high resistance to proteolysis and have the ability to bind to cell membranes, leading to disruption of the integrity of pathogenic cells and explaining the antimicrobial properties. At the same time, specific interaction with phosphatidylethanolamine-containing areas of bacterial membranes allows avoiding toxic effects on the epithelium.

Indirect data indicate modulation of tyrosinase activity with external use of Clitoria ternatea extracts, which may be associated with competitive inhibition of the enzyme by anthocyanin structures. This explains the lightening effect at the level of epidermal melanocytes. The ability of active substances to suppress the activity of metalloproteinases (especially MMP-2 and MMP-9) has also been described, which potentially reduces the degradation of the intercellular matrix in the skin.

Additionally, an effect on the regulation of monoamine levels (dopamine, serotonin) with systemic use of extracts has been shown, presumably through a MAO-interfering effect; however, the mechanism remains insufficiently studied. Reversible inhibitory activity against monoamine oxidase-A (MAO-A) has been established, without disturbing the overall CNS homeostasis at physiological doses.

References:
https://pubmed.ncbi.nlm.nih.go...
https://www.ncbi.nlm.nih.gov/p...
https://www.sciencedirect.com/...
https://pubmed.ncbi.nlm.nih.go...
https://www.sciencedirect.com/...

Synergy — Clitoria ternatea

According to pharmacological studies, Clitoria ternatea demonstrates pronounced synergy with a number of plant extracts and natural substances when used together. The most stable direction of synergistic interaction is the potentiation of antioxidant activity. The combined use of Clitoria ternatea with Camellia sinensis (green tea) enhances the inactivation of free radicals due to the additive effect of anthocyanins and catechins, confirmed in biochemical test systems.

In interaction with Bacopa monnieri, a potentiating effect on neuromodulating effects is observed, including the regulation of cholinergic and glutamate receptors. This is explained by the combined action on acetylcholinesterase and BDNF expression, which has been shown in animal behavioral models. Such a combination demonstrates additive and partly modulating characteristics.

An enhanced anti-inflammatory response has also been recorded when combining extracts of Clitoria ternatea with Curcuma longa. Curcuminoids and anthocyanins simultaneously inhibit NF-κB and reduce TNF-α and IL-1β levels, while Clitoria ternatea also suppresses iNOS expression, providing additional anti-inflammatory potential.

Synergy with Withania somnifera is realized primarily at the level of adaptogenic and anxiolytic action. Combined use has a cumulative effect on the HPA (hypothalamus-pituitary-adrenal) axis and helps reduce corticosteroid levels. An enhancement of GABA-mimetic activity has been established when combining these taxa.

Separately, the interaction of Clitoria ternatea with natural oils (coconut, argan) should be noted, which serve as a transport base and simultaneously facilitate the penetration of lipophilic components of the plant during external use. Such combinations show a potentiating and protective effect at the epidermal level.

References:
https://pubmed.ncbi.nlm.nih.go...
https://pubmed.ncbi.nlm.nih.go...
https://www.sciencedirect.com/...
https://link.springer.com/arti...
https://www.tandfonline.com/do...

Geography of Use and Traditional Medicine — Clitoria ternatea

Clitoria ternatea is traditionally used in the folk medicine and ritual practice of several regions of Southeast Asia, South Asia, East Africa, and the Caribbean Basin. It is most widely represented in the phytotherapeutic traditions of India, Thailand, Vietnam, Myanmar, Sri Lanka, Indonesia, as well as in the cultures of the Malay Archipelago. In the Ayurvedic system, clitoria is known as "shankhapushpi" and is among the revered rasayana plants. It was traditionally used in the form of powder, aqueous and oil infusions, decoctions, and wraps. Its aerial parts and roots were part of multi-component mixtures used for general strengthening of the body and spirit.

In Thai and Lao folk medicine, the blue flowers of the plant are used to prepare an infusion that is used externally and internally. They were considered a cooling and cleansing principle, especially during hot weather. In northern Thailand and in the ritual practices of the Lanna people, the plant symbolized wisdom and protection, and its flowers were included in ceremonial wreaths and protective amulets intended for women and children. In mythological symbolism, the color of clitoria was associated with heavenly purity and the favor of the house spirit.

In Philippine village medicine, the plant was used as a remedy for cleansing hair and scalp, as well as a coloring agent for ritual drinks and ritual baths during seasonal holidays. In Indonesia, plant extracts were included in traditional herbal ointments and pastes intended for women in the postpartum period.

In southern China and the Tibetan cultural area, references have been preserved to the use of clitoria in the form of powders and smoking mixtures in rituals for cleansing dwellings from disease spirits. In Malay and Javanese cultures, the plant was considered a "female flower" that protects against the evil eye and was used in wedding ceremonies and initiation rituals.

According to archaeoethnobotanical data, clitoria has been recorded in ritual and household burials in Madhya Pradesh (India) around the 3rd century BC. References to the plant under similar names are found in the medical treatises of the Charaka school and in post-Vedic texts, where it is described as a remedy for cleansing and strengthening the mind.

In the oral tradition of the peoples of Central Africa, a similar plant with blue flowers is mentioned, used as protection against "heat of the soul" and the scattered spirit.